Applied Nutriceuticals Neovar 'Recomped' - 240 Caps

FREQUENTLY ASKED QUESTIONS

Q: What’s the difference between NeoVar  and every other creatine product out there?

A: NeoVar is the only creatine product to match the CRfree 40/PCr 60 ratio found in the naturally occurring human skeletal intramuscular creatine pool. Our proprietary, Mono/PCr complex™ and is chemically identical to what is stored in your working muscles. Therefore, skeletal muscle “recognizes” and assimilates the creatine in a more refined manner, allowing for a significant degree of uptake enhancement in skeletal muscle tissue. Furthermore, the insulin mimetic compounds included in the formula further enhance these benefits.  By combining to enhance intramuscular creatine deposition within skeletal muscle tissue.

Q: How long will it take to notice the positive effects of NeoVar?

A: Many users report a noticeable boost in volume and pump after the first use. As intra-muscular creatine phosphate levels increase, so will the benefits of NeoVar. The most potent effects of NeoVar are experienced once the muscle is fully saturated with creatine which usually occurs within 9-14 days, at which point you will notice your muscles are markedly fuller, vascular and more defined.

Q: Do you recommend ingesting protein and simple carbohydrates such as dextrose post-workout along with NeoVar?

A:  Yes. Depending on your body weight, dosages of 50-100 grams of simple carbohydrates post-workout followed by 30-50 grams of protein are recommended. The carbohydrates help fuel muscle repair during this important nutrient window, and the protein provides the building blocks for growth. The highly available creatine in NeoVar is a catalyst when paired with high dosages of protein post-workout.

Q: How does banaba extract mimic insulin?

A: Banaba extract has been used for years in Eastern medicine to control diabetes, but it is a relatively new compound to Western medicine.  Corosolic acid, the active ingredient in banaba extract, closely mimics insulin by stimulating much greater glucose and creatine phosphate transport into cells. It accomplishes this by translocating GLUT4, while preventing plasma insulin levels from rising.  GLUT4 (glucose isoform 4) is a hormone that regulates the amount of glucose allowed into skeletal muscle cells.   In some comparison studies with insulin, banaba actually performed with equal effectiveness as insulin at controlling blood sugar, mostly due to the muscular GLUT4 translocation.  While corosolic acid has a mechanism of action similar to insulin, it does have a distinct advantage in that it is not an “equal opportunity” deposition agent, like insulin. Insulin does not discriminate the deposition of glucose, protein and creatine into your cells, whether they are muscle or fat cells, while corosolic acid has a much greater propensity to deliver these nutrients only to skeletal muscle. Also, when the body produces too much insulin over time, it begins to become insensitive to the hormone, which ultimately leads to increased fat storage and increases the risk of developing type II diabetes.

Q: How does corosolic acid drive more creatine into my muscle?

A: Corosolic acid has been shown to increase GLUT4 translocation in diabetic patients by allowing for greater glucose disposal in the muscle cells while keeping plasma insulin levels constant. The administration of corosolic acid as an insulin mimicking/glucose control agent can actually have repartitioning effects. Nutrient repartitioning is a process where creatine, glucose, and protein are deposited in the muscle cells, while blocking fat from being deposited in adipocytes (fat cells), as can occur with insulin. This is very important, because the more simple carbohydrates ingested after a workout, the more blood glucose, and the more blood glucose and creatine there is deposited into the muscle.  This can help the athlete retain a more positive nitrogen balance, greatly enhancing recovery and building muscle.

Q: What does the gymnema sylvestra and D-Pinitol do in this formula?

A: Gymnemic acid (the active ingredient in Gymnema sylvestre) closely mimics insulin by SAFELY stimulating much greater glucose into cells while not allowing plasma insulin levels to increase.  It has also been plausibly theorized that with this increased cellular transport of glucose, there will also be an increased transport of creatine phosphate into the cell.   In some studies where they conducted direct comparisons with insulin, gymnemic acid actually performed just as well as insulin at controlling blood sugar. D-pinitol can increase glycogen synthesis in the muscle cells, particularly in the absence of insulin. Additionally, the main reason D-Pinitol truly shines in this formulation is that it has been clinically proven to enhance creatine storage in the muscle cells of human subjects.

Q: What role does the Bioperine® play?

A: Bioperine (piperine 95%) is essentially an absorption aid; it increases the uptake of protein, amino acids, and creatine, as well as other supplements and nutrients.  Bioperine is hugely important because it allows the stomach and small intestine to absorb much greater proportions of the other active ingredients in NeoVar, along with any post-workout protein and carbohydrates.  Bioperine also decreases the breakdown of many nutrients by the liver, allowing for greater amounts of active ingredients to stay in the bloodstream for a longer period of time; making them more available for uptake by hard-working muscles.

Q: Who can benefit from NeoVar?

A: Everyone can benefit from taking in more creatine. It’s a natural healing element that will help speed recovery time, drives nutrients into the cells, and promotes insulin sensitivity.

Q: How long should I use NeoVar?

A: NeoVar can be used continuously as a “staple” part of your diet and supplementation program.

Q: How should I take NeoVar?

A: Best results are realized by taking NeoVar twice daily with carbohydrates; once post-workout then with any other meal containing carbs. Some users have reported phenomenal pumps by taking NeoVar pre-workout along with a glass of juice to fuel a mind-blowing workout.

Q: How long will a bottle of NeoVar last?

A: Since the dosage is dependant on body weight, it will vary. For a 250 lb.+ male, we recommend 4 capsules taken twice per day, so a 240-count bottle will provide even the biggest guys will have a full 30-day supply.

TECHNICAL WRITE UP

By combining the latest principles of nutritional technology with ancient Ayurvedic medicine, Applied Nutriceuticals research and development team has developed the most potent and biologically efficient post-workout nutrient enhancement product on the market.  A precisely proportioned combination of Phosphocreatine and creatine monohydrate (Mono/PCr complex™) is the primary element, which plays a vital role in cellular energy production by regenerating ATP in skeletal muscle and makes it available for explosive exercises (1-5).  Another important component of NeoVar, Corosolic Acid is extracted from the Banaba plant, a medicinal herb that grows in India, Southeast Asia, and the Philippines. It has been used for centuries as a treatment for hyperglycemia and diabetes, and the hypoglycemic effect is chemically very similar to that of the hormone insulin (7-11). Insulin is a polypeptide anabolic storage hormone, and is a crucial hormone in creatine transport and is necessary for the deposition of creatine phosphate in skeletal muscle.  NeoVar also adds a high-quality extract of gymnema sylvestra, an herb native to central India, where it has been used as a natural treatment for diabetes for over 2,000 years.  Gymnemic acid, the main active constituent of gymnema, has anti-sweetener, anti-inflammatory, and anti-diabetic attributes and its effects also closely mimic those of insulin (13-16).  Bioperine® (piperine 95%) is also included in the formulation and has been shown in clinical studies to enhance the uptake of amino acids and many other nutrients, allowing protein, carbohydrates, creatine, and other nutrients to be more avaliable to supply hard-working muscle (40).  The final component of NeoVar, D-Pinitol, is a cutting-edge compound that enhances nitric oxide production and insulin sensitivity which are key factors in nutrient transport.  D-Pinitol has also been shown in human studies to enhance intramuscular creatine deposition in human clinical studies (30). The individual effects of these compounds combine synergistically to produce a dramatic positive impact on the strength, size, and endurance of skeletal muscle tissue.

The theory behind the synergism of the Mono/PCr Complex is quite simple: It aims to match the CRfree 40/PCr 60 ratio of the naturally occurring human skeletal intramuscular creatine pool as closely as possible; allowing for greater absorption and utilization with minimal waste. The product is blended to maximize PCr levels, while at the same time including monohydrate due to its high molar percentage of creatine as the active ingredient.  Human skeletal muscle creatine stores are comprised of approximately 40% in the free creatine form (CRfree), while the remaining 60% is in the phosphorylated form; creatine phosphate (CP).  The Mono/PCr complex in NeoVar essentially feeds both CRfree levels and phosphocreatine levels in this optimized ratio, which is chemically identical to what is stored in the working muscles (1,3-5).  Several animal studies have confirmed that CRfree has better availability for site phosphorylation for the production of ATP, and further studies are currently underway on the validation of this theory in humans. Similarly, research on phosphate has concluded that it has numerous benefits in the athletic realm even without creatine, especially in terms of buffering lactic acid during explosive exercise.  Phosphate supplementation raises levels of 2,3-diphosphoglycerate (2,3-DPG), the enzyme that unloads oxygen into muscle. Research has shown that phosphate supplementation reliably raises blood levels of 2,3-DPG, and also improves the production and use of glycogen for fuel Therefore, this blend of both CRfree and PCr could allow skeletal muscle to “recognize” and assimilate the creatine in a more refined manner, allowing for a significant degree of uptake enhancement in skeletal muscle tissue (32-38). Additionally, the insulin mimetic compounds included in the formula may even further enhance these benefits. 

A recent trend in creatine supplementation has been the development of exotic esters and alkaline/time-released delivery systems. In developing NeoVar, we researched virtually every creatine derivative currently available before arriving with the final formulation. We analyzed numerous and often conflicting studies regarding the benefits of each and found many of the so-called improvements actually reduced the effectiveness of the products they were used in. Ultimately we elected to avoid this trend, which is proving to be more about company’s efforts to differentiate their products than actual effectiveness. Some of our findings include:

1. Many of the esters and delivery systems included in some of the newer products can be potentially difficult for the body to metabolize; the creatines included in NeoVar are essentially pure creatine, water, and phosphate and contain no other byproducts that could potentially hinder utilization.

2. Esters are simply fatty acid chains attached to a parent substance (in this case, creatine) that delay absorption and/or release; the newer esterified creatines actually contain less creatine, and more fatty acid chains that have no use in any type of physiological process.  Several low-quality products use versions with longer esters and are only 20-30% creatine, with the rest being useless fatty acids.

3.  Recent human research studies have proven that many of the alkaline creatine delivery systems actually do not work as well as creatine phosphate or creatine monohydrate as far as absorption in the digestive system and ultimately in skeletal muscle (43).

In developing NeoVar, we sought to use the molecules proven in numerous human studies to replicate the exact physiological ratios found in the intramuscular creatine pool in human skeletal muscle so the body can recognize and utilize it readily.

Creatine Phosphate Molecule

Creatine provides a variety of anabolic effects on skeletal muscle, increasing lean body mass while being a source of ATP (adenosine tri-phosphate, a source of cellular energy that aids in muscle contraction). Increased creatine phosphate inside the muscle cell is a powerful anabolic stimulus for muscle hypertrophy. Increased CP stores in the muscle allow for greater intracellular water retention.  Greater intracellular water retention from increased CP raises osmotic pressure within the cell, allowing for heightened protein synthesis and nitrogen retention.  Heightened protein synthesis and nitrogen retention create an optimal anabolic environment for intense muscular growth (2-4).    Creatine uptake into the muscle can also be influenced by glucose, insulin and insulin-sensitizing agents, as the correct manipulation of these entities can allow for much larger amounts of creatine to be stored within the muscle cells.  This is the main goal of NeoVar- to allow for the greatest amounts of creatine to be stored in working muscle through the manipulation of different nutrients, because as we all know, the more creatine you can hold in your muscles, the more your muscles will recover and grow (1-6).

ATP-PCr System

There are many other potential benefits to creatine supplementation.  Creatine boosts the activity of myogenic cells, which are satellite stem cells that have the ability to turn themselves into new muscle cells if instructed to do so by the genetic code of the body.  These satellite cells fuse with an adjacent damaged muscle fiber, thereby increasing myonucleii numbers necessary for growth and repair.  This process of myogenic maturation is called hyperplasia, and the subsequent new muscle cells formed by hyperplasia also have the ability to enable muscle hypertrophy (growth) if combined with weight training (4). 

As we know, creatine supplementation increases intramuscular creatine stores, but to greatly varying extents. Many manufacturers suggest an initial loading dose to accelerate creatine saturation within the cell; however this method commonly produces uncomfortable abdominal cramps and bloating. In the early 90's researchers discovered that ingesting creatine w/ high glycemic carbohydrates such as dextrose dramatically raised skeletal muscle concentrations of creatine beyond regular oral supplementation alone.  More recent research has found that taking creatine with glucose (25-100 g), or with combinations of glucose and protein (around 30-40 grams of each macronutrient) allows for larger amounts of creatine storage due to the increased insulin secreted in response to the carbohydrate intake (1,5,6). Up to 60% increases in intracellular creatine were noted in some subjects (a 20% raise is considered normal in most studies) using these methods, but the results varied greatly (6). While moderately effective, these techniques fall short because most ingested creatine is still not absorbed. The unabsorbed creatine accumulates outside of the targeted cells, causing a multitude of negative side effects including bloating, cramping and dehydration. The objective when developing NeoVar was to discover other compounds that can further aid in greater uptake of intramuscular creatine. 

The level of creatine uptake into muscle is influenced greatly by intramuscular creatine concentration and extracellular concentrations of glucose and insulin. The ingestion of high glycemic carbohydrates (such as dextrose, fructose, and sucrose) causes a large increase in blood glucose, and concurrent to this rise in blood glucose, a surge (or “spike”) of insulin is released from the pancreas in order to control the amount of sugar in the blood. Since insulin is necessary in transporting creatine and blood glucose into skeletal muscle,   the increased insulin drives greater creatine uptake into muscle (1,5,6). The amount of intramuscular creatine concentration and extracellular concentrations of glucose and insulin influence the degree of absorption into the cell. This is important, in that individuals who supplement with creatine and who have low muscle creatine and phosphocreatine levels are more responsive to creatine supplementation. The additional insulin released in response to the ingestion of carbohydrates (which convert to glucose) helps drive more creatine into the cell (6).

Therefore, taking creatine with products that can safely and effectively alter insulin levels and/or sensitivity   such as banaba extract and gymnema sylvestre may enhance creatine uptake and retention. While these two herbs have been used for years in Eastern medicine to control diabetes, they are very new compounds to Western science.  Corosolic acid (the active ingredient in Banaba extract) and gymnemic acid (the active ingredient in Gymnema sylvestre) closely mimic insulin by SAFELY stimulating much greater glucose into cells while not allowing plasma insulin levels to increase.  It has also been plausibly theorized that with this increased cellular transport of glucose, there will also be an increased transport of creatine phosphate into the cell (7-19).   In some studies where they conducted direct comparisons with insulin, corosolic acid and gymnemic acid actually performed just as well as insulin at controlling blood.

Insulin Sensitivity Graphically Illustrated

sugar in patients with Type II diabetes.  Therefore while corosolic acid and gymnemic acid have a mechanism of action similar to insulin, they do have a distinct advantage over insulin, in that it is not an “equal opportunity” deposition agent, like insulin. In other words, insulin can be problematic and beneficial at the same time, in that while it can increase deposition of glucose, protein and creatine into the muscles, it can also have a negative effect by increasing body fat levels.  Plus, when the body produces too much insulin over time, it begins to become insensitive to the hormone, resulting in a down-regulation of insulin receptors on target tissue (7-10, 13-21).  

Gymnemic acid has also been shown to interact with receptors on the tongue to decrease the sensation of sweetness in many foods. This action has been shown to reduce blood sugar and cholesterol levels in diabetic animals and humans and may provide some benefits in terms of regulating appetite control and food cravings (19,20).  Research have isolated at least nine different fractions of gymnemic acid, with each fraction possessing glucose-repartitioning activity (21-24).  The effect of gymnemic acid on lowering glucose levels in the blood is gradual, usually typically taking a few days. Very high doses of gymnemic acid may even help to repair the cellular damage that causes diabetes (by helping to regenerate the insulin producing beta-cells in the pancreas). Human studies on gymnema in diabetes treatment have shown significant reduction in blood glucose, glycosylated hemoglobin (an index of blood sugar control) and insulin requirements (so insulin therapy could be reduced) (23).  There appears to be due to an increase in the effectiveness of insulin with gymnema, rather than causing the body to produce more – although the precise mechanism by which this occurs remains unknown. As with other natural ingredients for control of blood sugar and insulin levels, such as corosolic acid, a common “side effect” is weight loss – probably due to a combination of appetite suppression and control of food cravings (especially for carbohydrates and sweets) (19-24).

Insulin, Glucose, and Glut-4 Translocation

Corosolic Acid (the active ingredient in Banaba Extract) has been shown to increase GLUT4 translocation in human studies.  GLUT4 (muscle facilitative glucose isoform 4, a transporter protein) translocation is important because GLUT4 is a transporter protein that regulates the amount of glucose allowed into skeletal muscle cells.  Corosolic acid increases the ability of the body to regulate the amount of glucose coming into a cell, and in diabetic patients, this allows for greater glucose disposal in the muscle cells.  This keeps plasma insulin levels the same, meaning that the intake of corosolic acid as an insulin mimicking/glucose control agent has significant nutrient repartitioning effects (7-11).  In this case, nutrient repartitioning means that while creatine, glucose, and protein are being deposited in the muscle cells, fat is not being deposited in adipocytes (fat cells), as is the case with insulin (8).   This is very important, because when more simple carbohydrates are ingested after a workout, it can be theorized that more blood glucose (and creatine) are deposited into the muscle. This can help the athlete retain a more positive nitrogen balance, thus enhancing recovery and building mass, making corosolic acid and gymnemic acid important components that contribute to the profound affects of NeoVar (8-10).

Bioperine®

Bioperine (piperine 95%) is a revolutionary compound that can increase the uptake of protein, amino acids, and creatine, as well as other supplements and nutrients.  A simple 10-20 mg daily dose of this substance can increase the uptake of all of these components from 30-150%. Bioperine is hugely important in the formulation of NeoVar as an effective post-workout recovery and growth enhancement product, because it allows the stomach and small intestine to absorb much greater proportions of the other active ingredients in NeoVar, along with post-workout protein and carbohydrates.  Bioperine also decreases the breakdown of many nutrients by the liver, allowing for greater amounts of active ingredients to stay in the bloodstream for a longer period of time; making them more available for uptake by hard-working muscles.  This helps users of NeoVar recover much faster, therefore allowing for quicker gains in strength, lean muscle mass, and overall physique enhancement (40-42).  

Increased Nutrient Uptake of Coenzyme Q-10 (top) and Curcumin (bottom) with Bioperine

 

D-Pinitol

The cutting-edge compound D-Pinitol is also an integral component of NeoVar.  In recent studies, d-pinitol stimulated glucose uptake to an extent similar to that of insulin (26-30). In the presence of a low insulin concentration a synergistic effect was observed between pinitol and insulin, namely pinitol increased the effectiveness of insulin.  In addition, d-pinitol can increase glycogen synthesis in the muscle cells, particularly in the absence of insulin. However, the main reason D-Pinitol truly shines in this formulation is that it has been clinically proven to enhance creatine storage in human subjects.  Creatine loading alone has been reported to increase muscle creatine and phosphocreatine stores by 5 to 30% (1-4).  

Percentage of creatine retained during the 3 day loading period for the placebo (P), creatine monohydrate (CM), low-dose D-pinitol (LP), high-dose D-Pinitol (HP), and pre-D-Pinitol loading (Pre-P) groups.  Data are means±SD. a = p<0.05 from placebo ; b=p<0.05 from CM ;  c=p<0.05 from LP ;  d=p<0.05 from HP ;  e=p<0.05 from Pre-P.

A study done by Greenwood in 2001 (see above) found that low-dose d-pinitol supplementation can indeed enhance whole-body creatine deposition more so than creatine alone, or creatine and high-dose d-pinitol.  Another important factor to note is that this increase in creatine storage occurred completely independent of carbohydrate intake, meaning that the user could potentially have the same effects from a d-pinitol/creatine mixture as they would with a carbohydrate/d-pinitol/creatine mixture (see below) (31).

Insulin-Like Response of D-Pinitol

Essentially, NeoVar combines the benefits of the most biologically available creatines with compounds that channel them into hard-working muscle cells more quickly, efficiently and completely than any other product ever produced. Precisely dosed, and in convenient capsules, no other product delivers the goods like NeoVar…at any price.

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43.  Tallon MJ1 and Child R2. Kre-alkalyn® supplementation has no beneficial effect on creatine-to-creatinine conversion rates. 1University of Northumbria, Sport Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne, United Kingdom.2Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom.